Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Human bodies are frail, easily damaged packages full of parts that can never fully come back once lost. Luckily, researchers worldwide are working on replacing every bit of the body to make us all cyborgs.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Matt Damon was named best actor in a comedy or musical motion picture for his role as a stranded astronaut in The Martian.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
The girl, said to be from Shanghai, paid the man between 1,900 and 9,500 yuan every day over a two-month period through online payments using her mother's mobile phone and debit card.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
The University of St Gallen’s domination of the Financial Times’ ranking of masters in management courses continues for another year.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Trends and targets in antiviral phototherapy
Gongloff piles on the bad news about 2014: GDP 'grew at a 1.8% annualized pace in the first quarter ... revising down its earlier estimate of 2.4% growth ... The first quarter's dismal growth was at least better than the 0.4% GDP growth of the fourth quarter of 2012. But it was still far from healthy, and economists don't see it getting much stronger any time soon.' And that's real bad news for the markets going into 2014.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
A Former First Lady Presses On for a Tolerant, Feminist Islam
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
A Former First Lady Presses On for a Tolerant, Feminist Islam
2.You Never Have a Day When You Wake Up Excited To Go To Work
Diagnostic technologies for COVID-19: a review
“…was snervous she almost fainted.”
The 15 ranked online MBA programmes provide flexible study options for working executives, who can expect to graduate with the same qualification as their full-time, residential MBA counterparts.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Usually sober-minded analysts, accustomed to the auto industry’s slow growth, seem to shed their inhibitions when it comes to Tesla. Rod Lache of Deutsche Bank has attached a $310 price target on the stock. Not to be out-done, Adam Jonas of Morgan Stanley established a $320 price target and calls Tesla it the “most important car company in the world”.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
补救办法： 做预算。 如果你不能估算需要多少钱才能过上令你感到舒适的生活，你就无法确切地知道为了1万美元薪水而换工作是否真的划算。在比较新、旧工作时，列出各自的优缺点，这会对你很有帮助。如果新工作只是薪水更高一点，那么你可以比较下这个工作是否要求更长的工作时间和完成更多的工作任务。请记住，调查表明：年收入在7.5万美元以内，幸福感会随着薪水的增加而增加，但是一旦薪水超过这个水平，幸福感的增加便不再明显。因此，如果你认为薪水增加到8.5万或9万美元会使你更加快乐，这时你或许应该着手解决生活中那些与金钱无关而引起的不快乐。
China's expenditure on technology research and development rose 10.6% to 1.57 trillion yuan in 2016, the fastest annual growth since 2014, as the nation increases its investment in new driving forces to stabilize the economy.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Russia and Nato have both called for a de-escalation of the Turkey-Netherlands row.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
All those totals are higher than a year ago, with the largest growth being in market value (up 13% year-over-year). These firms employ 90 million people worldwide.
Antiviral drug discovery: broad-spectrum drugs from nature
This elegant, informative and borderline beautiful sentence is a reminder that despite the horrific nature of the entries below, clarity remains attainable.
Analysts believe the launch will help Apple to overcome its growth problem of the last two years. In markets such as America and Europe, where smartphone ownership is close to saturation and many customers are holding on to their existing handsets for longer, the best way to drive faster revenue growth is by charging more for each device, rather than simply relying on unit growth.
Influenza neuraminidase: A druggable target for natural products
This is the second year running that Peking University has reached the height of No. 2 university.
The parents of a number of stars have ended up with their Oscar-winning child’s awards. Angeline Jolie’s late mum, for a number of years, had the best supporting actress award her daughter won for her role as the troubled Lisa Rowe in Girl, Interrupted. Nicole Kidman’s best actress Oscar for The Hours now sits on her parents’ mantelpiece in Sydney, where neighbours apparently pass by for visits. Hollywood’s darling du jour, Jennifer Lawrence, keeps the award she won last year for her leading role in Silver Linings Playbook on top of her parents’ piano at home in Kentucky.
This year brought so many promising new shows: 2014 was the year of “True Detective,” “The Honorable Woman,” “Fargo,” “The Affair,” “Olive Kitteridge” and “Silicon Valley," among others. But there were also older shows that either stayed the course or somehow climbed their way back from a dip or even total eclipse, notably “The Comeback,” starring Lisa Kudrow, a HBO comedy that was canceled in 2005 after one season and then resurrected in November.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
So, what does that mean for oil prices in 2015? It is anybody’s guess, but here are the top five variables that will determine the trajectory of oil prices over the next 12 months, in no particular order.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Will a stable and liquid bitcoin futures market develop
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Jiang Yiyi, deputy director of the Institute of International Tourism at the China Tourism Academy, attributed part of the dropoff in foreign tourists to the strengthening yuan.
The raised decoration shows a cartouche — an oval frame around Egyptian hieroglyphics indicating a royal name. Above the frame archaeologists could make out the symbol of an eye and that of a cobra.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
For the fourth year in a row, the top five places continue to be dominated by the same five intercontinental EMBAs. Tiemba came top this year not by spectacularly outperforming its rivals but thanks to a strong performance across most indicators. In particular, the alumni have the second highest salary on average ($324,000) behind alumni from the Kellogg/HKUST programme ($408,000). Tiemba is also ranked second for career progression and fourth for work experience.
A Method to the Madness
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The gorgeous Birman cat has more than 128,000 Instagram followers. And it has been the inspiration for many of Lagerfeld's designs.
7. “Out 1: Noli Me Tangere”(Jacques Rivette)
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
WhatsApp had been particularly ad-averse before its sale to Facebook. CEO Jan Koum kept a note from co-founder Brian Acton taped to his desk to remind him of the company’s core values. It read: “No Ads! No Games! No Gimmicks!”
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
1."The Little Kicks" in Seinfeld Almost Didn't Happen
WORST USE OF SOCIAL MEDIA
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
No.5: What Made Phelps So Happy?
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
adj. 已被确认的，确定的，建立的，制定的 动词est
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
'In the meantime, the U.S. continues to grow its own domestic production both in oil and gas. I think, for us, it's less about where the actual price is going--it's more about how much more growth is left in North American oil sands, shale gas, shale oil,' as well as shale exploration elsewhere, he said.
St Gallen outperforms other ranked schools thanks in part to strong scores for international criteria. More than 90 per cent of students and 80 per cent of faculty are from abroad. The school is also ranked second for both the international mobility of its students and their international exposure during the programme.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Now a white-haired grandfather, Belmonte has never regretted missing the 1950 match, particularly since his mother died just a few days later. "I decided not to go, and it was a good decision," he told the reporters.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Sorry, folks, but if you're an investor hoping America's political internecine wars will improve in the near future, just don't invest. The war between Congress with it's abysmal 10% approval rating and the president, the war between the Dems, GOP and the tea party, is going to get even worse, upsetting markets and the economy even more.
In addition to the overall ranking, US News also offers region-, country- and subject-specific rankings, to allow for more tailored searching.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
6. Gene therapy comes good.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
“He’s had more of a sense of swagger and confidence” in recent months, says Jan Dawson of Jackdaw Research.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
'If that happens, that will need to be offset by some reduction of production out of Saudi [Arabia],' said Neil Gregson, a fund manager at J.P. Morgan Asset Management who oversees $3.5 billion in natural-resources investments.
As for his own education: He's weighing whether to enroll in university in England or maybe the U.S. to be closer to Silicon Valley. Or perhaps he'll skip college entirely and just focus on his work. 'I absolutely want to start another company,' he says. 'Serial entrepreneurs get addicted to creation. I want to be passionate. I feel really bad when I'm not doing something new.'
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The 2018 Academic Ranking of World Universities released last Wednesday by Shanghai Ranking Consultancy reveals that 62 research universities in China have made their list of the world's top 500 universities.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
“The environment is gaining increasing appreciation from policymakers,” Alistair Hewitt, head of market intelligence at the World Gold Council, said. “Gold mining has come under tighter regulations.”
Chinese Cultural Relics is a new journal that translates Chinese-language articles, originally published in the journal Wenwu, into English. The discovery of the 1,700-year-old cemetery was included in its inaugural issue.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
P2P lending has grown quickly in the past two years, with loans outstanding reaching Rmb209bn by the end of June, according to E-Lending House.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
"China is Australia's most valuable tourism market, with the potential to be worth more than $13 billion by 2020."
A modular microarray imaging system for highly specific COVID-19 antibody testing
日前，斯坦福大学商学院(Stanford Graduate School of Business)教授彼得o库迪斯基于这场荷兰危机共同撰写了一篇文章，围绕“个人经验（而非市场信息）决定乐观、悲观以及信贷的获得与否”这种不那么科学的方法给出了现代经验。
To be brief, people with type C personalities are perfectionists, consistent and will never break the rules. Unlike their "sister" type A; type C personalities tend to take their time with the details and often check and recheck their work for accuracy. They tend to be deep thinkers and like to know every detail in regards to their work and life.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Andersl?v, Sweden was plagued by residents with green hair. Johan Pettersson discovered that there was too much copper in their water.
Ranking third on our Top-Grossing list is Steve Carell. Despicable Me 2 was a huge hit this year, bringing in $919 million at the box office. Overall, the franchise has earned $1.4 billion at the box office worldwide and a third movie, Minions, is on the way. Carell also appeared this year in the small indie The Way Way Back and The Incredible Burt Wonderstone. The latter failed to earn back its production budget at the box office but we’re only looking at ticket sales here — the film put another $22.5 million in Carell’s column for 2013.
Well, what you do makes me cry at night. You grown ups say you love us. I challenge you, please make your actions reflect your words. Thank you for listening. 然而，你们所做的事让我在夜晚哭泣，你们成年人说你们爱我们，我不会再相信了，因为只有行动和语言的合一，才是找回信任和未来的唯一方法！谢谢！
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Although no North American cities feature in the top 20, the EIU said the cost of living in New York had risen relative to other places in the United States. It shares 27th position as the most expensive US city with Los Angeles.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Inarritu said: "I forgot to thank all the native Americans who made this film possible. I cannot say how surprised I am and how proud I am to have survived this film with all these fellows."
1997：H5N1传染人类1997: H5N1 Infects Humans
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The most badass super-villains assigned to protecting people, that's Suicide Squad for you. A government agency called A.R.G.U.S recruits villains to perform dangerous tasks that in turn reduces their prison sentence. The task force includes Joker, Deadshot, Harley Quinn, Boomerang, Killer Croc and several other villains from the DC Comics universe.
According to a research report on 2016 graduates released by 51job.com, a leading job hunting platform in China, 52.11% of college graduates found employment or started their own business.
Best Companies rank: 11
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The pipelines were building in spite of poor performance for this year’s high-profile deal from Snap, the owner of Snapchat, in the US and investor concerns that a strengthening euro may curtail the earnings recovery in Europe.
6. 查理兹-塞隆 1650万美元
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
主流网络游戏仍然是大型多人在线角色扮演游戏 (MMORPG)。报告说，今年10月，中国最热门的10款网络游戏中有6款都属于大型多人在线角色扮演游戏。动视暴雪(Activision Blizzard)开发的《魔兽世界》(World of Warcraft)在注册用户和最高同时在线人数方面仍然排名榜首。但报告指出，目前围绕着这款游戏大陆运营权的政府监管纷争可能会给《魔兽世界》带来负面影响。网易公司目前持有《魔兽世界》的中国大陆独家运营权。
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Han emphasized that the risk of infection still remains because college students, who are sexually active, might have unprotected sex because they are susceptible to external influences.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
The Tsinghua-Insead EMBA programme, launched in 2007, entered the FT rankings with a bang in 2012, going straight into fourth place with its very first cohort. The programme has since been ranked second, third, and finally has achieved first place in the rankings this year.
At its Worldwide Developer Conference in June, Mr Cook was mobbed by app makers who asked him to pose for selfies. By October’s iPad launch, he was even cracking jokes at his own expense. Clad in his habitual but unglamorous uniform of black untucked shirt and jeans, he said that Apple Watch had been well received by “people who know a lot about fashion and style — even more than I do”, pointing a knowing finger at the chuckling audience.
Finding Dory releases on June 17, 2016.
Length-scale dependence of protein hydration-shell density
Similarly, Katy Perry was initially granted a visa to perform at the show in Shanghai but Chinese officials soon changed their mind. This, it has been claimed, is because the singer carried a Taiwanese flag and wore a dress covered in sunflowers during a 2015 concert in Taiwan.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
As if 2016 hadn’t been hard enough for China’s workforce, an annual survey has revealed that more than half of the country’s white-collar employees got no year-end bonus ahead of the upcoming (and costly) lunar new year holiday.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
1. China’s Economy.China is the second largest consumer of oil in the world and surpassed the United States as the largest importer of liquid fuels in late 2013. More importantly for oil prices is how much China’s consumption will increase in the coming years. According to the EIA, China is expected burn through 3 million more barrels per day in 2020 compared to 2012, accounting for about one-quarter of global demand growth over that timeframe. Although there is much uncertainty, China just wrapped up a disappointing fourth quarter, capping off its slowest annual growth in over a quarter century. It is not at all obvious that China will be able to halt its sliding growth rate, but the trajectory of China’s economy will significantly impact oil prices in 2015.
About this collection